I WOULD HAVE EXPECTED MORE FROM OXFORD
Hydroxychloroquine is no good? You need to know how to use it!
I will show first on a simple sketch how hydroxychloroquine is supposed to be used to treat Covid-19
https://www.youtube.com/watch?v=MhLD1P5nH30
No clinical benefit from use of hydroxychloroquine in
hospitalised patients with COVID-19
RESEARCHCORONAVIRUSSCIENCE
A new statement has been released from the Chief
Investigators of the Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial
on hydroxychloroquine.
Professor Peter Horby and Professor Martin Landray, chief
investigators of the RECOVERY Trial, said ‘In March this year, RECOVERY was
established as a randomised clinical trial to test a range of potential drugs
for COVID-19, including hydroxycholoroquine.
‘The trial has proceeded at unprecedented speed, enrolling
over 11,000 patients from 175 NHS hospitals in the UK. Throughout this time,
the independent Data Monitoring Committee has reviewed the emerging data about
every two weeks to determine if there is evidence that would be strong enough
to affect national and global treatment of COVID-19.
‘On Thursday 4 June, in response to a request from the UK
Medicines and Healthcare Products Regulatory Agency (MHRA), the independent
Data Monitoring Committee conducted a further review of the data. Last night,
the Committee recommended the chief investigators review the unblinded data on
the hydroxychloroquine arm of the trial.
‘We have concluded that there is no beneficial effect of
hydroxychloroquine in patients hospitalised with COVID-19. We have therefore
decided to stop enrolling participants to the hydroxychloroquine arm of the
RECOVERY trial with immediate effect. We are now releasing the preliminary
results as they have important implications for patient care and public health.
‘A total of 1542 patients were randomised to
hydroxychloroquine and compared with 3132 patients randomised to usual care
alone. There was no significant difference in the primary endpoint of 28-day
mortality (25.7% hydroxychloroquine vs. 23.5% usual care; hazard ratio 1.11
[95% confidence interval 0.98-1.26]; p=0.10). There was also no evidence of
beneficial effects on hospital stay duration or other outcomes.
‘These data convincingly rule out any meaningful mortality
benefit of hydroxychloroquine in patients hospitalised with COVID-19. Full
results will be made available as soon as possible.
Peter Horby, Professor of Emerging Infectious Diseases and
Global Health in the Nuffield Department of Medicine, University of Oxford, and
Chief Investigator for the trial, said: ‘Hydroxychloroquine and chloroquine
have received a lot of attention and have been used very widely to treat COVID
patients despite the absence of any good evidence. The RECOVERY trial has shown
that hydroxychloroquine is not an effective treatment in patients hospitalised
with COVID-19. Although it is disappointing that this treatment has been shown
to be ineffective, it does allow us to focus care and research on more
promising drugs.’
Martin Landray, Professor of Medicine and Epidemiology at
the Nuffield Department of Population Health, University of Oxford, and Deputy
Chief Investigator, said, ‘There has been huge speculation and uncertainty
about the role of hydroxychloroquine as a treatment for COVID-19, but an
absence of reliable information from large randomised trials. Today’s
preliminary results from the RECOVERY trial are quite clear –
hydroxychloroquine does not reduce the risk of death among hospitalised
patients with this new disease. This result should change medical practice
worldwide and demonstrates the importance of large, randomised trials to inform
decisions about both the efficacy and the safety of treatments.’
Full details of the study protocol and related materials are
available at www.recoverytrial.net
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